Abortion in neural tube defect fraternities.

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Abortion in neural tube defect fraternities.

Fraternities that include a fetus or person with a neural tube defect are remarkable for a high rate of recurrence of this type of malformation, about seven to eight times the overall rate (Record and McKeown, 1950; MacMahon, Pugh, and Ingalls, 1953; Carter, David, and Laurence,1968) and a higher than average rate of abortions (Murphy, 1940; Record and McKeown, 1950). Murphy (1940) found that a...

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Neural Tube Defect and Folic Acid

نقص لوله عصبی یکی از ناهنجاریهای مادرزادی مهم و شایع می باشد که شیوع آن بیش از ۵/ ۴ در ۱۰۰۰ تولد زنده است. اتیولوژی و پاتوژنز بیماری هنوز ناشناخته است. مطالعات اخیر بر روی حیوانات نشان می دهد که این ناهنجاری ممکن است، ناشی از متابولیسم غیر طبیعی هموسیستئین باشد. در مطالعات اخیر مشخص شده است که پیشگیری از نقص لوله عصبی (NTD) بوسیله اسیدفولیک مؤثر می باشد.

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Prenatal Screening for Neural Tube Defect

Neural tube defect (NTD) is a serious congenital defect, but current methods for identifying NTD are limited. We used proteomic analysis of maternal serum to identify NTD-specific proteins whose levels differed between women with NTD fetuses (n = 50) and those with healthy fetuses (n = 40). Three NTD-specific protein peaks (8,130.6, 15,941.7, and 3,960.3 m/z) were identified using MALDI-TOF-mas...

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Area differences in spontaneous abortion rates in South Wales and their relation to neural tube defect incidence.

Data are presented from the South Wales Congenital Malformation Survey (92,982 births 1964-6 inclusive) showing that within areas in South Wales there exists an inverse relation between previous spontaneous abortion rate and the prevalence at birth of neural tube defect (anencephaly or spina bifida cystica or both). This relation is independent of social class, parity, and maternal age, and is ...

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Rudimentary meningocele: remnant of a neural tube defect?

BACKGROUND Rudimentary meningocele, a malformation in which meningothelial elements are present in the skin and subcutaneous tissue, has been described in the past under a variety of different terms and has also been referred to as cutaneous meningioma. There has been debate as to whether rudimentary meningocele is an atretic form of meningocele or results from growth of meningeal cells displac...

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ژورنال

عنوان ژورنال: Journal of Epidemiology & Community Health

سال: 1971

ISSN: 0143-005X

DOI: 10.1136/jech.25.4.220